Patchett S, Beattie S, Keane C, O'Morain C
Department of Gastroenterology, Meath/Adelaide Hospitals, Trinity College, Dublin, Eire.
Aliment Pharmacol Ther. 1992 Feb;6(1):113-7. doi: 10.1111/j.1365-2036.1992.tb00551.x.
Thirty consecutive patients with endoscopically proven duodenal ulceration who had Helicobacter pylori infection on culture and histology, were treated with tripotassium dicitrato bismuthate (1 tablet q.d.s., 400 mg metronidazole t.d.s. and 500 mg tetracycline t.d.s. for one week, followed by the bismuth salt for a further 3 weeks. All patients were endoscoped at entry and 4 weeks after cessation of treatment, to check for ulcer healing and H. pylori eradication. Two antral biopsies were taken at each endoscopy for histological and microbiological evidence of H. pylori infection. Complete healing of duodenal ulcers was observed in 27/30 patients (90%). Gastritis improved or completely resolved in 26 patients. Eradication of H. pylori was achieved in 27 patients. Of the three patients who failed to heal, two were H. pylori-positive at follow-up and one was H. pylori-negative.
连续30例经内镜证实为十二指肠溃疡且培养和组织学检查显示有幽门螺杆菌感染的患者，接受了枸橼酸铋钾治疗（每日4次，每次1片），同时服用甲硝唑每日3次，每次400mg以及四环素每日3次，每次500mg，疗程1周，之后继续服用铋盐3周。所有患者在入组时及治疗结束后4周接受内镜检查，以检查溃疡愈合情况及幽门螺杆菌根除情况。每次内镜检查时均取两块胃窦活检组织，用于幽门螺杆菌感染的组织学和微生物学证据检查。30例患者中有27例（90%）十二指肠溃疡完全愈合。26例患者的胃炎得到改善或完全缓解。27例患者实现了幽门螺杆菌根除。在未愈合的3例患者中，2例在随访时幽门螺杆菌呈阳性，1例呈阴性。
