Luesley D
Dudley Road Hospital, University of Birmingham, UK.
Curr Opin Obstet Gynecol. 1992 Feb;4(1):102-8.
Cervical intraepithelial neoplasia remains a significant problem with regard to diagnosis and treatment. The emphasis has now shifted toward selection for treatment, partly as a result of an improved understanding of risk and partly as a result of simple excisional methods of treatment with low morbidity. It is now apparent that diagnoses based on small directed biopsy specimens may be misleading and whole transformation zone specimens should be regarded as the ideal. Although the role of oncogenic human papillomaviruses still remains obscure with regard to the etiology of cervical intraepithelial neoplasia, continued investigation is essential and rewarding in terms of an improved understanding of the molecular biology of malignant transformation and the interaction of transformed cells with the host's immune system.
宫颈上皮内瘤变在诊断和治疗方面仍然是一个重大问题。目前重点已转向治疗选择，部分原因是对风险有了更好的理解，部分原因是采用了发病率低的简单切除治疗方法。现在很明显，基于小的定向活检标本的诊断可能会产生误导，整个转化区标本应被视为理想标本。尽管致癌性人乳头瘤病毒在宫颈上皮内瘤变的病因学方面的作用仍不明确，但持续的研究对于更好地理解恶性转化的分子生物学以及转化细胞与宿主免疫系统的相互作用至关重要且富有成效。
