Sison A V
Georgetown University Medical Center, Washington, D.C.
Curr Opin Obstet Gynecol. 1992 Feb;4(1):48-54.
Acquired immunodeficiency virus infections had recently been the leading cause of death in minority women of reproductive age in several urban cities in the United States. In addition, more than 80% of infants with human immunodeficiency virus type 1 infection acquired the infection perinatally. These alarming data have spawned a prodigious body of information about perinatal human immunodeficiency virus type 1 infection. Some of the most recent advances are highlighted in this review. Revolutionary techniques, initially developed in molecular biology, such as in situ hybridization, the polymerase chain reaction, and gene sequencing, have also recently made a significant contribution to the diagnosis and better understanding of viral and bacterial infections. For example, organisms such as cytomegalovirus, herpes simplex, Chlamydia, parvovirus, Pneumocystis carinii, and toxoplasma are now detectable by polymerase chain reaction methods. The most recent information in these areas is also briefly reviewed.
获得性免疫缺陷病毒感染最近已成为美国几个城市中育龄少数族裔女性的主要死因。此外，超过80%的1型人类免疫缺陷病毒感染婴儿是在围产期感染的。这些惊人的数据催生了大量关于围产期1型人类免疫缺陷病毒感染的信息。本综述重点介绍了一些最新进展。最初在分子生物学中开发的革命性技术，如原位杂交、聚合酶链反应和基因测序，最近也对病毒和细菌感染的诊断以及更好的理解做出了重大贡献。例如，现在可以通过聚合酶链反应方法检测到巨细胞病毒、单纯疱疹病毒、衣原体、细小病毒、卡氏肺孢子虫和弓形虫等生物体。这些领域的最新信息也将简要回顾。
