Frey K W
Rofo. 1979 Feb;130(2):172-4. doi: 10.1055/s-0029-1231246.
Following the application of 10 000 to 15 000 rd, to 471 patients with benign goitres, mechanical symptoms were relieved in 72 to 82% during a course of six follow-up examinations; the circumference of the neck was reduced by 1.2 to 1.6 cm., the scintigraphic area by 9 to 31% and maximal 131I uptake was reduced by 18 to 31%. Follow-up examinations at 6.4 and 5.5 years in 155 patients showed the best regression of neck circumference (2.2 to 2.6 cm.) and of the area of the scintigram (28 to 31%). 50% of the patients had had recurrences from previous goitre removals and 1 to 3% developed post-therapeutic hypothyroidism. There was no significant change in the level of the peripheral thyroid hormones following treatment, but 10 to 20% were within the hypothyroid range for the area of iodine deficiency.
对471例良性甲状腺肿患者给予10000至15000拉德的照射后，在为期6次的随访检查过程中，72%至82%的患者机械性症状得到缓解；颈部周长减少了1.2至1.6厘米，闪烁扫描面积减少了9%至31%，最大131碘摄取量减少了18%至31%。对155例患者进行的6.4年和5.5年随访检查显示，颈部周长（减少2.2至2.6厘米）和闪烁扫描面积（减少28%至31%）的消退情况最佳。50%的患者既往有甲状腺肿切除术后复发情况，1%至3%的患者出现治疗后甲状腺功能减退。治疗后外周甲状腺激素水平无显著变化，但10%至20%的患者处于碘缺乏地区甲状腺功能减退范围内。
