Vergote I B, Onsrud M, Børmer O P, Sert B M, Moen M
Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo.
Gynecol Oncol. 1992 Feb;44(2):161-5. doi: 10.1016/0090-8258(92)90032-e.
The presence of CA125 was assessed in peritoneal fluid from 70 patients with ovarian cancer and 32 control patients. The follow-up period ranged from 39 to 89 months (median, 56 months). The cutoff for normal peritoneal fluid CA125 levels was determined to be 250 U/ml. A positive correlation between the serum and peritoneal fluid CA125 levels was observed (P less than 0.001). Peritoneal fluid levels were higher than serum levels in all patients. Patients with evidence of active ovarian cancer showed higher peritoneal fluid CA125 levels than the control patients (P less than 0.001). Peritoneal fluid CA125 levels correlated inversely with survival (P = 0.004). The peritoneal fluid CA125 levels were higher in patients with bulky tumor than in those with small (less than 1 cm) tumors (P less than 0.001). Eight out of twenty-six patients with active cancer and available peritoneal cytology had a negative peritoneal cytology. Three of these patients showed elevated peritoneal fluid levels. Three patients out of twenty-four showed elevated peritoneal fluid CA125 levels at second-look laparotomy. These 3 patients had negative biopsies at second-look surgery, but relapsed during the observation period. At second-look laparotomy an elevated peritoneal fluid CA125 level may imply a bad prognosis, but a normal level does not exclude the presence of disease.
对70例卵巢癌患者和32例对照患者的腹腔液进行了CA125检测。随访期为39至89个月（中位数为56个月）。正常腹腔液CA125水平的临界值确定为250 U/ml。观察到血清和腹腔液CA125水平呈正相关（P<0.001）。所有患者的腹腔液水平均高于血清水平。有活动性卵巢癌证据的患者腹腔液CA125水平高于对照患者（P<0.001）。腹腔液CA125水平与生存率呈负相关（P = 0.004）。肿瘤体积大的患者腹腔液CA125水平高于肿瘤小（小于1 cm）的患者（P<0.001）。26例有活动性癌症且可进行腹腔细胞学检查的患者中，8例腹腔细胞学检查为阴性。其中3例患者腹腔液水平升高。24例患者中有3例在二次剖腹探查时腹腔液CA125水平升高。这3例患者二次手术活检为阴性，但在观察期内复发。二次剖腹探查时腹腔液CA125水平升高可能预示预后不良，但水平正常并不能排除疾病存在。
