Andrews B S, McIntosh J, Petts V, Penny R
Int Arch Allergy Appl Immunol. 1979;58(3):313-21. doi: 10.1159/000232207.
39 patients with acute anterior uveitis were investigated for the presence of circulating immune complex (IC) and correlation with the major histocompatibility complex antigen B27 (HLA-B27). ICs were demonstrated by a number of techniques including rheumatoid factor, complement (C) activation, anticomplementary activity, cryoglobulins, inhibition of IgG-EA rosette formation and neutrophil chemotactic index (NCI) in plasma. ICs were most frequently detected in HLA-B27-negative patients. These results indicate that deposition of circulating ICs may be involved in the pathogenesis of acute anterior uveitis, especially in HLA-B27-negative patients.
对39例急性前葡萄膜炎患者进行了循环免疫复合物（IC）检测及其与主要组织相容性复合体抗原B27（HLA - B27）相关性的研究。采用多种技术检测IC，包括类风湿因子、补体（C）激活、抗补体活性、冷球蛋白、抑制IgG - EA花环形成以及血浆中的中性粒细胞趋化指数（NCI）。IC最常出现在HLA - B27阴性患者中。这些结果表明，循环IC的沉积可能参与急性前葡萄膜炎的发病机制，尤其是在HLA - B27阴性患者中。
