葡萄膜炎中的补体激活
Complement activation in uveitis.
作者信息
Vergani S, Di Mauro E, Davies E T, Spinelli D, Mieli-Vergani G, Vergani D
出版信息
Br J Ophthalmol. 1986 Jan;70(1):60-3. doi: 10.1136/bjo.70.1.60.
Abstract
To determine whether complement is activated in uveitis we have measured plasma levels of C3d, a sensitive indicator of complement activation. Increased levels of C3d were found in 11 of 15 patients with idiopathic uveitis, 13 of whom had circulating immune complexes containing complement components. Since during complement activation potent mediators of inflammation are generated, it is suggested that the activation of complement, possibly triggered by uveal deposition of immune complexes, has an important role in the pathogenesis of uveitis.
摘要
为了确定葡萄膜炎中补体是否被激活，我们检测了C3d的血浆水平，C3d是补体激活的一个敏感指标。在15例特发性葡萄膜炎患者中，有11例C3d水平升高，其中13例循环免疫复合物中含有补体成分。由于在补体激活过程中会产生强效炎症介质，因此提示补体激活可能由免疫复合物在葡萄膜沉积触发，在葡萄膜炎发病机制中起重要作用。
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