Tan Min-Han, Rogers Craig G, Cooper Jeffrey T, Ditlev Jonathon A, Maatman Thomas J, Yang Ximing, Furge Kyle A, Teh Bin Tean
Laboratory of Cancer Genetics, and Bioinformatics Special Program, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.
Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6315S-21S. doi: 10.1158/1078-0432.CCR-050002.
Renal cell carcinoma (RCC) is a histologically diverse disease, with variable and often unpredictable clinical behavior. The prognosis worsens dramatically with the onset of clinical metastasis, and current regimens of systemic therapy yield only modest benefits for metastatic RCC. Gene expression profiling is a promising technique for refining the diagnosis and staging of RCC, as well as for highlighting potential therapeutic targets. We review the recent advances in expression profiling of RCC and discuss the clinical and biological insights obtained from these studies.
肾细胞癌（RCC）是一种组织学上具有多样性的疾病，其临床行为多变且往往不可预测。随着临床转移的出现，预后会急剧恶化，而目前的全身治疗方案对转移性RCC仅产生适度的益处。基因表达谱分析是一种很有前景的技术，可用于完善RCC的诊断和分期，以及突出潜在的治疗靶点。我们回顾了RCC表达谱分析的最新进展，并讨论了从这些研究中获得的临床和生物学见解。
