Stolz U, Saur F, Gugler E
Helv Paediatr Acta. 1977 Jul;32(2):155-63.
Nonketotic hyperosmolar diabetic coma is a rare manifestation of juvenile diabetes, in contrast to adult onset diabetes. To date only 20 cases have been published, the majority of them infants and toddlers. This type of diabetic coma is seen with unusual frequency in children with Down's syndrome and psychomotor retardation. The clinical picture is characterised by severe dehydration, hyperglycemia with often extremely high blood sugar levels, hyperosmolarity and glucosuria without ketonuria. Mortality in children has been high (24%). This paper reports the case of a 14-month-old girl with Down's syndrome. Clinical and therapeutic as well as pathogenetic aspects are discussed.
非酮症高渗性糖尿病昏迷是青少年糖尿病的一种罕见表现，与成人发病的糖尿病不同。迄今为止，仅发表了20例病例，其中大多数是婴幼儿。这种类型的糖尿病昏迷在唐氏综合征和精神运动发育迟缓的儿童中出现的频率异常高。临床表现的特点是严重脱水、高血糖且血糖水平常常极高、高渗状态以及糖尿但无酮尿。儿童患者的死亡率一直很高（24%）。本文报告了一名患有唐氏综合征的14个月大女孩的病例。对临床、治疗以及发病机制方面进行了讨论。
