van Rossum A M C, Wulkan R W, Oudesluys-Murphy A M
Medical Centre Rijnmond-Zuid, Rotterdam, Netherlands.
Lancet Infect Dis. 2004 Oct;4(10):620-30. doi: 10.1016/S1473-3099(04)01146-6.
A child or neonate presenting with fever is a common medical problem. To differentiate between those with a severe bacterial infection and those with a localised bacterial or a viral infection can be a challenge. This review provides an overview of neonatal and paediatric studies that assess the use of procalcitonin as an early marker of bacterial infection. Procalcitonin is an excellent marker for severe, invasive bacterial infection in children. However, the use of procalcitonin in the diagnosis of neonatal bacterial infection is complicated, but if correctly used procalcitonin results in a higher specificity than C-reactive protein. In addition, procalcitonin has been shown to correlate with severity of disease (urinary tract infections and sepsis), and can therefore be used as a prognostic marker. Procalcitonin is therefore a useful additional tool for the diagnosis of bacterial disease in neonates and children.
发热的儿童或新生儿是常见的医学问题。区分患有严重细菌感染的患儿与患有局部细菌感染或病毒感染的患儿可能具有挑战性。本综述概述了评估降钙素原作为细菌感染早期标志物应用的新生儿和儿科研究。降钙素原是儿童严重侵袭性细菌感染的优秀标志物。然而,降钙素原在新生儿细菌感染诊断中的应用较为复杂,但如果正确使用,降钙素原的特异性高于C反应蛋白。此外,降钙素原已被证明与疾病严重程度(尿路感染和脓毒症)相关,因此可作为预后标志物。因此,降钙素原是诊断新生儿和儿童细菌性疾病的一种有用的辅助工具。