B族链球菌感染时血清炎症因子的变化及其对胎膜早破合并绒毛膜羊膜炎的预测价值。
Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis.
作者信息
Dong Xiaorui, Chen Xixi, Xue Mengling, Zhang Yina
机构信息
Department of Obstetrics, Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, 310000, China.
出版信息
Biomark Med. 2024;18(7):301-309. doi: 10.2217/bmm-2023-0588. Epub 2024 Apr 16.
The aim of this study as to unveil changes in serum inflammatory factors in pregnant women with genital tract group B (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes. The value of serum inflammatory factor levels in predicting PROM complicating CS and adverse pregnancy outcomes in GBS-infected pregnant women was evaluated by ELISA. Serum IL-6, TNF-α, PCT and hs-CRP levels were higher in pregnant women with GBS infection. The combined diagnosis of these factors had excellent diagnostic value in PROM complicating CS and adverse pregnancy outcomes. Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.
本研究旨在揭示生殖道B族（GBS）感染孕妇血清炎症因子的变化及其对胎膜早破（PROM）合并绒毛膜羊膜炎（CS）及不良妊娠结局的预测价值。采用酶联免疫吸附测定法（ELISA）评估血清炎症因子水平对GBS感染孕妇发生PROM合并CS及不良妊娠结局的预测价值。GBS感染孕妇的血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）和超敏C反应蛋白（hs-CRP）水平较高。这些因子的联合诊断对PROM合并CS及不良妊娠结局具有良好的诊断价值。IL-6、TNF-α、PCT和hs-CRP的联合预测对PROM合并CS及不良妊娠结局具有最佳预测价值。
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