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Novel Biomarkers: Soluble Urokinase-Type Plasminogen Activator Receptor and Procalcitonin- and Histological Chorioamnionitis after Preterm Premature Rupture of Membranes.新型生物标志物：可溶性尿激酶型纤溶酶原激活物受体与早产胎膜早破后降钙素原和组织学绒毛膜羊膜炎。
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本文引用的文献

1
Prevention of Early-Onset Neonatal Group B Streptococcal Disease: A Comprehensive Review of Major Guidelines.预防早发型新生儿 B 群链球菌病：主要指南的综合评价。
Obstet Gynecol Surv. 2023 Dec;78(12):766-774. doi: 10.1097/OGX.0000000000001223.
2
The Role of the Interleukin-1 Family in Complications of Prematurity.白细胞介素-1 家族在早产儿并发症中的作用。
Int J Mol Sci. 2023 Feb 1;24(3):2795. doi: 10.3390/ijms24032795.
3
Eu-Chelate Polystyrene Microsphere-Based Lateral Flow Immunoassay Platform for hs-CRP Detection.基于 Eu-Chelate 聚苯乙烯微球的 hs-CRP 检测侧向流免疫分析平台。
Biosensors (Basel). 2022 Nov 7;12(11):977. doi: 10.3390/bios12110977.
4
Chorioamnionitis and neonatal outcomes.绒毛膜羊膜炎与新生儿结局。
Pediatr Res. 2022 Jan;91(2):289-296. doi: 10.1038/s41390-021-01633-0. Epub 2021 Jul 1.
5
Ascertaining the Prevalence of Group B Streptococcal Infection in Patients with Preterm Premature Rupture of Membranes: A Cross-Sectional Analysis from Pakistan.确定胎膜早破早产患者中B族链球菌感染的患病率：来自巴基斯坦的横断面分析。
Cureus. 2021 Feb 17;13(2):e13395. doi: 10.7759/cureus.13395.
6
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†.炎症在良性妇科疾病中的作用：从发病机制到新疗法。
Biol Reprod. 2021 Jul 2;105(1):7-31. doi: 10.1093/biolre/ioab054.
7
Tocolytic Therapy in Preterm Premature Rupture of Membranes.早产胎膜早破的保胎治疗。
Obstet Gynecol Clin North Am. 2020 Dec;47(4):569-586. doi: 10.1016/j.ogc.2020.08.003. Epub 2020 Oct 7.
8
Upregulation of TNF-α and IL-6 induces preterm premature rupture of membranes by activation of ADAMTS-9 in embryonic membrane cells.TNF-α 和 IL-6 的上调通过激活胚胎膜细胞中的 ADAMTS-9 诱导早产胎膜早破。
Life Sci. 2020 Nov 1;260:118237. doi: 10.1016/j.lfs.2020.118237. Epub 2020 Aug 8.
9
Burden of Adults Hospitalized With Group B Streptococcal Infection.成人患 B 群链球菌感染住院的负担。
J Infect Dis. 2021 Oct 13;224(7):1170-1178. doi: 10.1093/infdis/jiaa110.
10
Management of Group B Streptococcus-Positive Women With Preterm Premature Rupture of the Membranes: Still a Therapeutic Dilemma.B族链球菌阳性且胎膜早破早产女性的管理：仍然是一个治疗难题。
J Obstet Gynaecol Can. 2018 Dec;40(12):1627-1631. doi: 10.1016/j.jogc.2018.06.006. Epub 2018 Oct 24.

B族链球菌感染时血清炎症因子的变化及其对胎膜早破合并绒毛膜羊膜炎的预测价值。

Changes in serum inflammatory factors in group B streptococcal infection and their predictive value for premature rupture of membranes complicated by chorioamnionitis.

作者信息

Dong Xiaorui, Chen Xixi, Xue Mengling, Zhang Yina

机构信息

Department of Obstetrics, Women's Hospital School of Medicine Zhejiang University, Hangzhou, Zhejiang, 310000, China.

出版信息

Biomark Med. 2024;18(7):301-309. doi: 10.2217/bmm-2023-0588. Epub 2024 Apr 16.

DOI:10.2217/bmm-2023-0588
PMID:38623925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11218798/
Abstract

The aim of this study as to unveil changes in serum inflammatory factors in pregnant women with genital tract group B (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes. The value of serum inflammatory factor levels in predicting PROM complicating CS and adverse pregnancy outcomes in GBS-infected pregnant women was evaluated by ELISA. Serum IL-6, TNF-α, PCT and hs-CRP levels were higher in pregnant women with GBS infection. The combined diagnosis of these factors had excellent diagnostic value in PROM complicating CS and adverse pregnancy outcomes. Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.

摘要

本研究旨在揭示生殖道B族（GBS）感染孕妇血清炎症因子的变化及其对胎膜早破（PROM）合并绒毛膜羊膜炎（CS）及不良妊娠结局的预测价值。采用酶联免疫吸附测定法（ELISA）评估血清炎症因子水平对GBS感染孕妇发生PROM合并CS及不良妊娠结局的预测价值。GBS感染孕妇的血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）和超敏C反应蛋白（hs-CRP）水平较高。这些因子的联合诊断对PROM合并CS及不良妊娠结局具有良好的诊断价值。IL-6、TNF-α、PCT和hs-CRP的联合预测对PROM合并CS及不良妊娠结局具有最佳预测价值。