降钙素原和C反应蛋白血清水平作为发热性中性粒细胞减少症和癌症患儿感染的标志物。
Procalcitonin and C-reactive protein serum levels as markers of infection in a pediatric population with febrile neutropenia and cancer.
作者信息
Martinez-Albarran Manuel, Perez-Molina Jose de Jesus, Gallegos-Castorena Sergio, Sanchez-Zubieta Fernando, Del Toro-Arreola Susana, Troyo-Sanroman Rogelio, Gonzalez-Ramella Oscar
机构信息
Departamento de Hematologia y Oncologia Pediatrica, Hospital Civil de Guadalajara Juan I. Menchaca, Guadalajara, Jalisco, Mexico.
出版信息
Pediatr Hematol Oncol. 2009 Sep;26(6):414-25. doi: 10.3109/08880010903044797.
BACKGROUND
Procalcitonin and C-reactive-protein are inflammatory markers for sepsis. The authors evaluated their sensitivity and specificity in pediatric patients with cancer and febrile neutropenia.
PROCEDURE
Serum procalcitonin and C-reactive-protein were evaluated. Patients (n = 54) were divided into 2 groups, with severe infection (n = 18) or without documented infection (n = 36).
RESULTS
Procalcitonin and C-reactive protein were significantly higher in the high-risk group. Procalcitonin displayed 72.2% sensitivity and 80.5% specificity. C-reactive-protein had a sensitivity of 77.7% and specificity of 77.2%.
CONCLUSIONS
Procalcitonin is an accurate predictor of bacterial infection in neutropenic children, while C-reactive-protein may be a better screening test in emergency settings.
背景
降钙素原和C反应蛋白是脓毒症的炎症标志物。作者评估了它们在患有癌症和发热性中性粒细胞减少症的儿科患者中的敏感性和特异性。
程序
对血清降钙素原和C反应蛋白进行评估。患者（n = 54）被分为两组，一组为严重感染（n = 18），另一组为无感染记录（n = 36）。
结果
高危组中的降钙素原和C反应蛋白显著更高。降钙素原的敏感性为72.2%，特异性为80.5%。C反应蛋白的敏感性为77.7%，特异性为77.2%。
结论
降钙素原是中性粒细胞减少儿童细菌感染的准确预测指标，而C反应蛋白可能是紧急情况下更好的筛查检测指标。
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