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监测欧洲黑色素瘤发病率的特定阶段趋势表明,需要更全面的诊断特征信息。

Monitoring stage-specific trends in melanoma incidence across Europe reveals the need for more complete information on diagnostic characteristics.

作者信息

de Vries E, Bray F I, Eggermont A M M, Coebergh J W W

机构信息

Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.

出版信息

Eur J Cancer Prev. 2004 Oct;13(5):387-95. doi: 10.1097/00008469-200410000-00006.

Abstract

Cutaneous malignant melanoma has been characterized by rapid and steady increases in incidence and mortality in white populations. Some reports mentioned declining trends in the mean thickness of these tumours, but other studies suggested a stable incidence of thick melanomas. The aim of this study was to describe the stage distribution of melanomas across Europe, with particular reference to temporal trends. Twenty-three cancer registries provided data sets containing information on stage and histology, 21 of which were used for a general description and nine for trends analyses. Despite a preponderance of missing data, interesting patterns emerged: a less favourable stage distribution in populations with relatively low incidence, but high case-fatality rates, and a favourable trend in stage and histology distribution over time, including a shift from later to earlier stages in recent years. Early detection campaigns raising awareness for thin lesions can potentially improve melanoma survival rates. Monitoring of stage-specific trends in melanoma incidence can assess the impact of such interventions. This paper demonstrates the potential utility of high-quality, timely cancer registry data in pursuing such public health objectives and addresses the need for more complete information on diagnostic features of melanoma patients. This will allow more informative evaluations of preventive strategies.

摘要

皮肤恶性黑色素瘤在白人人群中的发病率和死亡率一直呈快速且稳定的上升趋势。一些报告提及这些肿瘤的平均厚度呈下降趋势,但其他研究表明厚黑色素瘤的发病率稳定。本研究的目的是描述欧洲黑色素瘤的分期分布,尤其关注时间趋势。23个癌症登记处提供了包含分期和组织学信息的数据集,其中21个用于总体描述,9个用于趋势分析。尽管存在大量缺失数据,但仍出现了有趣的模式:在发病率相对较低但病死率较高的人群中,分期分布较差;随着时间推移,分期和组织学分布呈良好趋势,包括近年来从晚期向早期的转变。提高对薄病变认识的早期检测活动可能会提高黑色素瘤的生存率。监测黑色素瘤发病率的分期特定趋势可评估此类干预措施的影响。本文展示了高质量、及时的癌症登记数据在实现此类公共卫生目标方面的潜在效用,并指出需要获取关于黑色素瘤患者诊断特征的更完整信息。这将使对预防策略的评估更具参考价值。

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