Katalinic A, Kunze U, Schäfer T
Institute for Cancer Epidemiology, University of Lübeck, Beckergrube 43-47, 23552 Lübeck, Germany.
Br J Dermatol. 2003 Dec;149(6):1200-6. doi: 10.1111/j.1365-2133.2003.05554.x.
Population-based figures on skin cancer are essential for a realistic assessment of the personal disease burden, prevention modes and the need for caring. The Robert Koch Institute in Germany estimates the incidence of melanoma skin cancer as seven cases in 100 000 persons (age-standardized by the European standard rate). Population-based studies presumably show higher incidence rates of 10-16 cases in 100 000 persons. Few data exist for non-melanoma skin cancer (NMSC) as this is not systematically registered in Germany.
To present the first population-based results from the Schleswig-Holstein (Germany) Cancer Registry on incidence, stage distribution, clinical types and localization of skin cancer and to compare the results with other studies.
The Cancer Registry of the Bundesland Schleswig-Holstein with 3500 registering institutions, 100 of which are dermatological institutions, investigates all notifiable incident cancer cases according to international standards. From the recorded data all melanoma and NMSC cases were identified and evaluated.
Between 1998 and 2001, 1784 malignant melanoma (MM) and 12 956 NMSC cases underwent diagnostic and analytical evaluation. For MM, age-standardized incidence rates were 12.3 and 14.8 in 100 000 men and women, respectively, and the mean age of men was greater than that of women (56.6 vs. 54.9 years, P < 0.05). Superficial spreading melanoma was the most frequent clinical type (39.1%). The tumours were predominantly located on the trunk in men (46.8%) in contrast to leg and hip in women (39.5%). For NMSC, the age-standardized incidence rates were 100.2 and 72.6 in 100 000 men and women, respectively. More than 80% of all tumours were basal cell carcinoma.
The first population-based data from Schleswig-Holstein on the characteristics (age, sex, histological subtypes, localization and stage) of skin tumours agree well with the existing literature and may thus be regarded as representative. However, markedly higher incidences for MM and NMSC in the north of Germany compared with other parts of the country were observed. As the incidence rates from the north of Germany fit well into the European geographical pattern, we assume no regional increase. Therefore, the official German estimates on cutaneous tumours may largely depend on regional factors and may not be regarded as representative for all regions in Germany.
基于人群的皮肤癌数据对于切实评估个人疾病负担、预防模式及护理需求至关重要。德国罗伯特·科赫研究所估计皮肤黑色素瘤的发病率为每10万人中有7例（按欧洲标准率进行年龄标准化）。基于人群的研究推测显示发病率更高，为每10万人中有10 - 16例。关于非黑色素瘤皮肤癌（NMSC）的数据很少，因为在德国它没有系统登记。
呈现德国石勒苏益格 - 荷尔斯泰因癌症登记处关于皮肤癌发病率、分期分布、临床类型及部位的首批基于人群的结果，并将结果与其他研究进行比较。
石勒苏益格 - 荷尔斯泰因州的癌症登记处有3500个登记机构，其中100个是皮肤科机构，根据国际标准对所有应报告的新发癌症病例进行调查。从记录的数据中识别并评估所有黑色素瘤和NMSC病例。
1998年至2001年期间，1784例恶性黑色素瘤（MM）和12956例NMSC病例接受了诊断和分析评估。对于MM，年龄标准化发病率在男性和女性中分别为每10万人12.3例和14.8例，男性的平均年龄大于女性（56.6岁对54.9岁，P < 0.05）。浅表扩散性黑色素瘤是最常见的临床类型（39.1%）。肿瘤在男性中主要位于躯干（46.8%），而在女性中主要位于腿部和臀部（39.5%）。对于NMSC，年龄标准化发病率在男性和女性中分别为每10万人100.2例和72.6例。所有肿瘤中超过80%为基底细胞癌。
石勒苏益格 - 荷尔斯泰因州关于皮肤肿瘤特征（年龄、性别、组织学亚型、部位和分期）的首批基于人群的数据与现有文献吻合良好，因此可被视为具有代表性。然而，观察到德国北部的MM和NMSC发病率明显高于该国其他地区。由于德国北部的发病率与欧洲地理模式相符，我们认为不存在区域性上升。因此，德国官方对皮肤肿瘤的估计可能在很大程度上取决于区域因素，可能不能被视为代表德国所有地区。
