De Vleeschouwer Steven, Van Gool Stefaan W, Van Calenbergh Frank
Department of Neurosurgery, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Childs Nerv Syst. 2005 Jan;21(1):7-18. doi: 10.1007/s00381-004-0994-3. Epub 2004 Sep 28.
In this review, we discuss immunotherapy for malignant gliomas.
The emphasis is on the novel strategy of active specific immunotherapy using dendritic cells as antigen-presenting cells, especially its theoretical concepts and advantages, specific requirements, critical issues, pre-clinical and early clinical experience. Dendritic cell vaccination is situated in the diversity of other immunotherapeutical approaches.
Future directions, challenges, and drawbacks will be discussed.
在本综述中,我们讨论恶性胶质瘤的免疫治疗。
重点在于以树突状细胞作为抗原呈递细胞的主动特异性免疫治疗新策略,尤其是其理论概念和优势、具体要求、关键问题、临床前及早期临床经验。树突状细胞疫苗接种处于其他免疫治疗方法的多样性之中。
将讨论未来方向、挑战和缺点。