Braham-Jmili Néjia, Ltaief Amel, Ghorbel Hayet, Omri Halima, Mahjoub Touhami, Braham Youssef, Bahri Fethi, Jemni Letaief, Hedhili Abderrazek, Kortas Mondher
Laboratoire d'Hématologie, Clinique CHU Farhat Hached, Sousse, Tunisie.
Tunis Med. 2004 Apr;82(4):350-7.
Vitamin B12 belong a group of cobalamins. It's known to be an enzymatic cofactor of many metabolic reactions essentially in the synthesis of DNA. Damage of deficiency are various essentially hematologic and neurologic. Macrocytic anaemia constitute the main disorder of vitamin B12 deficiency. However, Vitamin B12 deficiency is common in the elderly with neuropsychiatric disorders whether macrocytic anaemia is present or not as its development may come later. In a study we investigate 95 patients aged 21 to 85 years (29 men, 20 women) with symptoms of vitamin B12 deficiency. First, vitamin B12 serum were measured by immuno enzymatic method (MEIA Abbott). Values were classified among 4 categories characterised on manufacture norms; low: 41 cases, unspecified: 19 cases, normal: 13 cases and high: 22 cases. Secondly, the concordance between Vitamin B12 serum, clinical history and evolution were evaluated. The Kappa index established showed a satisfactory result (= 0.97).
维生素B12属于钴胺素类。它是许多代谢反应的酶辅因子，主要参与DNA合成。缺乏维生素B12造成的损害多种多样，主要是血液学和神经学方面的。巨幼细胞贫血是维生素B12缺乏的主要病症。然而，维生素B12缺乏在患有神经精神疾病的老年人中很常见，无论是否存在巨幼细胞贫血，因为其症状可能在后期才出现。在一项研究中，我们调查了95名年龄在21至85岁之间（29名男性，20名女性）有维生素B12缺乏症状的患者。首先，采用免疫酶法（雅培MEIA）测定血清维生素B12水平。根据生产标准将数值分为4类：低：41例，未明确：19例，正常：13例，高：22例。其次，评估血清维生素B12水平、临床病史和病情发展之间的一致性。所建立的Kappa指数显示结果令人满意（=0.97）。
