Ito S, Tanaka A, Arakawa M, Nagata M, Ishikawa K, Katsuya H
Department of Anesthesiology, Anjo Kousei Hospital.
Masui. 1992 Jan;41(1):59-66.
The influence of thiopental administration on peripheral circulation during cardiac surgery with extracorporeal circulation was examined. The subjects were 28 patients who were divided into one group of 14 patients receiving thiopental and the other group of 14 patients receiving no thiopental. The time lag of changes in peripheral temperature (sole) from that in central temperature (forehead) according to the deep body temperature determination, and base excess were used as indices of the quality of the peripheral circulation. A single shot of thiopental at a dose of 4 mg.kg-1 was initially given i.v. at the start of extracorporeal circulation and subsequently thiopental at a dose of 2 mg.kg-1.hr-1 was continuously infused i.v. up to the time of the aortic declamping. The results indicate a significantly smaller lag in the group receiving thiopental than in the group receiving no thiopental. Base excess was maintained within normal limits in the former group compared with negative base excess in the latter group as well as a significantly smaller requirement of postoperative catecholamine in the former group. The above findings suggest that thiopental administration during cardiac surgery with extracorporeal circulation is not only useful for maintaining peripheral circulation, but also beneficial for post-operative cardiac function.
研究了硫喷妥钠给药对体外循环心脏手术期间外周循环的影响。研究对象为28例患者，分为两组，一组14例接受硫喷妥钠治疗，另一组14例未接受硫喷妥钠治疗。根据深部体温测定，外周温度（足底）与中心温度（额头）变化的时间差以及碱剩余被用作外周循环质量的指标。在体外循环开始时，首先静脉注射一剂4mg·kg-1的硫喷妥钠，随后以2mg·kg-1·hr-1的剂量持续静脉输注硫喷妥钠直至主动脉夹闭解除。结果表明，接受硫喷妥钠治疗的组的时间差明显小于未接受硫喷妥钠治疗的组。与后一组的负碱剩余相比，前一组的碱剩余维持在正常范围内，并且前一组术后儿茶酚胺的需求量也明显较少。上述研究结果表明，在体外循环心脏手术期间给予硫喷妥钠不仅有助于维持外周循环，而且对术后心脏功能有益。
