Trüeb Ralph M
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
Dermatology. 2004;209(3):202-7. doi: 10.1159/000079890.
Finasteride, an inhibitor of type 2 5alpha-reductase, inhibits conversion of testosterone to dihydrotestosterone, resulting in a decrease in serum and scalp dihydrotestosterone levels believed to be pathogenic in androgenetic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men, while its efficacy in women has remained controversial.
5 postmenopausal women without clinical or laboratory signs of hyperandrogenism were given 2.5 or 5 mg/day oral finasteride for the treatment of pattern hair loss. Efficacy was evaluated by patient and investigator assessments, and review of photographs taken at baseline and at months 6, 12 and 18 by an expert panel.
Finasteride treatment improved scalp hair by all evaluation techniques. The patients' self-assessment demonstrated that finasteride treatment decreased hair loss, increased hair growth and improved appearance of hair. These improvements were confirmed by investigator assessment and assessments of photographs. No adverse effects were noted.
Oral finasteride in a dosage of 2.5 mg/day or more may be effective for the treatment of pattern hair loss in postmenopausal women in the absence of clinical or laboratory signs of hyperandrogenism.
非那雄胺是一种2型5α-还原酶抑制剂，可抑制睾酮向二氢睾酮的转化，导致血清和头皮中二氢睾酮水平降低，而二氢睾酮水平被认为是雄激素性脱发的致病因素。口服非那雄胺已被证明对男性脱发治疗有效，但其对女性的疗效仍存在争议。
对5名无高雄激素血症临床或实验室体征的绝经后女性给予每日2.5毫克或5毫克的口服非那雄胺，用于治疗型脱发。通过患者和研究者评估以及由一个专家小组对基线时、第6、12和18个月拍摄的照片进行审查来评估疗效。
通过所有评估技术，非那雄胺治疗均改善了头皮毛发情况。患者的自我评估表明，非那雄胺治疗减少了脱发，增加了头发生长并改善了头发外观。这些改善得到了研究者评估和照片评估的证实。未观察到不良反应。
在无高雄激素血症临床或实验室体征的绝经后女性中，每日2.5毫克或更高剂量的口服非那雄胺可能对治疗型脱发有效。
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