Olsen Elise A, Hordinsky Maria, Whiting David, Stough Dow, Hobbs Stuart, Ellis Melissa L, Wilson Timothy, Rittmaster Roger S
Duke University Medical Center, Durham, North Carolina, USA.
J Am Acad Dermatol. 2006 Dec;55(6):1014-23. doi: 10.1016/j.jaad.2006.05.007.
Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor.
Our aim was to evaluate the efficacy of the type 1 and 2 5alpha-reductase inhibitor dutasteride in men with MPHL.
Four hundred sixteen men, 21 to 45 years old, were randomized to receive dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks.
Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride at 12 and 24 weeks. Expert panel photographic review and investigator assessment of hair growth confirmed these results. Scalp and serum dihydrotestosterone levels decreased, and testosterone levels increased, in a dose-dependent fashion with dutasteride.
The study was limited to 24 weeks.
Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.
男性型脱发（MPHL）是一种潜在可逆的病症，其中二氢睾酮是重要的病因因素。
我们的目的是评估1型和2型5α-还原酶抑制剂度他雄胺对男性型脱发男性的疗效。
416名年龄在21至45岁的男性被随机分配，每天接受0.05、0.1、0.5或2.5毫克度他雄胺、5毫克非那雄胺或安慰剂，持续24周。
与安慰剂相比，度他雄胺以剂量依赖的方式增加目标区域的毛发数量，并且在12周和24周时，2.5毫克度他雄胺优于非那雄胺。专家小组的照片评估和研究者对头发生长的评估证实了这些结果。度他雄胺使头皮和血清二氢睾酮水平呈剂量依赖性降低，睾酮水平呈剂量依赖性升高。
该研究仅限于24周。
度他雄胺可促进男性型脱发男性的头皮毛发生长。1型和2型5α-还原酶可能在男性型脱发的发病机制和治疗中起重要作用。
