Department of Dermatology, Universidade de São Paulo, São Paulo, SP, Brazil.
Department of Dermatology, Hospital do Servidor Publico Municipal de São Paulo, São Paulo, SP, Brazil.
Drugs. 2016 Sep;76(14):1349-64. doi: 10.1007/s40265-016-0629-5.
Androgenetic alopecia (AGA) is characterized by a non-scarring progressive miniaturization of the hair follicle in predisposed men and women with a pattern distribution. Although AGA is a very prevalent condition, approved therapeutic options are limited. This article discusses the current treatment alternatives including their efficacy, safety profile, and quality of evidence. Finasteride and minoxidil for male androgenetic alopecia and minoxidil for female androgenetic alopecia still are the therapeutic options with the highest level evidence. The role of antiandrogens for female patients, the importance of adjuvant therapies, as well as new drugs and procedures are also addressed.
雄激素性脱发(AGA)的特征是具有特定模式分布的易感男性和女性的毛囊进行性非瘢痕性缩小。尽管 AGA 是一种非常普遍的疾病,但批准的治疗选择有限。本文讨论了当前的治疗选择,包括它们的疗效、安全性概况和证据质量。非那雄胺和米诺地尔治疗男性雄激素性脱发,米诺地尔治疗女性雄激素性脱发仍然是具有最高证据水平的治疗选择。本文还讨论了女性患者的抗雄激素治疗、辅助治疗的重要性以及新药和新程序。