肥大细胞对病原体的反应。

Mast-cell responses to pathogens.

作者信息

Marshall Jean S

机构信息

Dalhousie Inflammation Group, Department of Microbiology and Immunology, Dalhousie University, Sir Charles Tupper Medical Building, College Street, Halifax, Nova Scotia B3H 1X5, Canada.

出版信息

Nat Rev Immunol. 2004 Oct;4(10):787-99. doi: 10.1038/nri1460.

DOI:10.1038/nri1460

PMID:15459670

Abstract

Mast cells have mainly been studied in the setting of allergic disease, but the importance of mast cells for host defence against several pathogens has now been well established. The location of mast cells, which are found closely associated with blood vessels, allows them to have a crucial sentinel role in host defence. The mast cell has a unique 'armamentarium' of receptor systems and mediators for responding to pathogen-associated signals. Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated.

摘要

肥大细胞主要是在过敏性疾病的背景下进行研究的，但现在已经充分证实肥大细胞在宿主抵御多种病原体方面具有重要作用。肥大细胞的位置与血管紧密相关，这使其在宿主防御中发挥关键的哨兵作用。肥大细胞拥有独特的受体系统和介质“武器库”，用于响应病原体相关信号。对这种有趣的免疫效应细胞的研究为启动适当的先天性和获得性免疫反应的复杂机制提供了重要见解。