Olson Erik J, Haskell Scott R R, Frank Rodney K, Lehmkuhl Howard D, Hobbs Lea Ann, Warg Janet V, Landgraf John G, Wünschmann Arno
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA.
J Vet Diagn Invest. 2004 Sep;16(5):461-4. doi: 10.1177/104063870401600518.
A dairy goat operation in Minnesota experienced a sudden, markedly increased mortality among its neonatal goats. Approximately 60 of 130 kids (46%) died. The animals had diarrhea and dyspnea of 1-2 days duration before death. Necropsy of 4 goat kids revealed marked, acute, catarrhal enteritis and fibrinous pleuropneumonia. Mannheimia haemolytica was isolated from the lungs. Basophilic inclusion bodies filling the entire nucleus were present in enterocytes of the ileum of 3 goats. Adenoviral particles were detected in the feces by electron microscopy and adenovirus was subsequently isolated from the intestinal content together with a parvo-like virus (dependovirus). Morphology, physicochemical characteristics, and neutralization tests indicated that the adenovirus resembled ovine adenovirus-2 (OAdV-2). However, the PstI restriction endonuclease pattern produced by the goat adenovirus was distinct from that of OAdV-2. This is the first report of enteritis in goats with an adenovirus antigenically related to OAdV-2 and with a parvo-like dependovirus.
明尼苏达州的一个奶山羊养殖场，新生山羊死亡率突然显著增加。130只小羊中约60只（46%）死亡。这些动物在死前1至2天出现腹泻和呼吸困难。对4只山羊幼崽进行尸检，发现有明显的急性卡他性肠炎和纤维素性胸膜肺炎。从肺部分离出溶血曼氏杆菌。3只山羊回肠的肠上皮细胞中存在充满整个细胞核的嗜碱性包涵体。通过电子显微镜在粪便中检测到腺病毒颗粒，随后从肠道内容物中分离出腺病毒以及一种细小病毒样病毒（依赖病毒）。形态学、理化特性和中和试验表明，该腺病毒类似于绵羊腺病毒2型（OAdV - 2）。然而，山羊腺病毒产生的PstI限制性内切酶图谱与OAdV - 2不同。这是首次报道与OAdV - 2抗原相关且伴有细小病毒样依赖病毒的山羊肠炎。
