Zhang Min, Zhang Yi-zhi, Wang Sheng, Wang Lin, Li Feng-yuan
Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):626-9.
To study the role of the dendritic cells, natural killer cells and adhesion molecules play in the pathogenesis of psoriasis.
The expression levels of human leukocyte antigen (HLA)-DR, CD1a, CD16, CD57, tumor necrosis factor (TNF)-alpha and intercellular adhesion molecule (ICAM)-1 were detected by immunohistochemistry in lesions of 26 patients with psoriasis before and after treatment.
The expression of HLA-DR, CD1a, CD16, CD57, TNF-alpha and ICAM-1 showed no significant difference between the active phase and the static phase of psoriatic lesions (P>0.05). After treatment, the positive expression of all markers decreased evidently or even disappeared with histopathological improvement in the resolvent phase of psoriatic lesions. There were statistically significant difference by Wilcoxon rank sum test (P<0.05).
Dendritic cells, natural killer cells and adhesion molecules play an important role in the pathogenesis of psoriasis.
研究树突状细胞、自然杀伤细胞及黏附分子在银屑病发病机制中的作用。
采用免疫组织化学法检测26例银屑病患者治疗前后皮损中人类白细胞抗原（HLA）-DR、CD1a、CD16、CD57、肿瘤坏死因子（TNF）-α及细胞间黏附分子（ICAM）-1的表达水平。
银屑病皮损活动期与静止期HLA-DR、CD1a、CD16、CD57、TNF-α及ICAM-1的表达差异无统计学意义（P>0.05）。治疗后，随着银屑病皮损消退期组织病理学改善，所有标志物的阳性表达明显降低甚至消失。经Wilcoxon秩和检验，差异有统计学意义（P<0.05）。
树突状细胞、自然杀伤细胞及黏附分子在银屑病发病机制中起重要作用。
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