Mozzanica N, Cattaneo A, Schmitt E, Diotti R, Finzi A F
Department of Dermatology, University of Milan, Italy.
Acta Derm Venereol Suppl (Stockh). 1994;186:171-2.
The aim of the present study was to investigate the distribution of Langerhans cells and T cells in the lesions and also the phenotypic expression of markers of activation on lesional T cells and keratinocytes, before and after 2 weeks of topical treatment of 7 psoriatic patients with calcipotriol. Before treatment, the infiltrate was composed mainly of T cells and there was decreased expression of CD1 on the intra-epidermal Langerhans cells. ICAM-1 and EGF receptor were present throughout the epidermis, but keratinocytes expressing Transferrin receptor were detected only in the basal layer. After 14 days of calcipotriol therapy, there were significantly fewer CD4T cells in the dermis and an increased number of intraepidermal CD1 + Langerhans cells. ICAM-1 expression on lesional keratinocytes was reduced in all patients, but the expression of EGF receptor was decreased in 3 patients only, and Transferrin receptor expression on keratinocytes had not changed. All these changes were concurrent with moderate clinical improvement of the lesions. The results suggest that in the early stages of the clinical response to calcipotriol there is an immunomodulating effect of the drug associated with variable decreases in keratinocyte expression of markers of activation.
本研究的目的是调查7例银屑病患者外用卡泊三醇治疗2周前后，皮损中朗格汉斯细胞和T细胞的分布情况，以及皮损T细胞和角质形成细胞上活化标志物的表型表达。治疗前，浸润细胞主要由T细胞组成，表皮内朗格汉斯细胞上CD1的表达降低。ICAM-1和表皮生长因子受体存在于整个表皮，但仅在基底层检测到表达转铁蛋白受体的角质形成细胞。卡泊三醇治疗14天后，真皮中CD4T细胞显著减少，表皮内CD1 +朗格汉斯细胞数量增加。所有患者皮损角质形成细胞上ICAM-1的表达均降低，但仅3例患者表皮生长因子受体的表达降低，角质形成细胞上转铁蛋白受体的表达未改变。所有这些变化都与皮损的中度临床改善同时出现。结果表明，在对卡泊三醇临床反应的早期阶段，该药物具有免疫调节作用，与角质形成细胞活化标志物表达的不同程度降低有关。
