[体外循环对人工瓣膜置换术患者围手术期血浆游离氨基酸谱的影响]
[Impact of cardiopulmonary bypass on free amino acid spectrum in plasma for patients with prosthetic valve replacement during the perioperative period].
作者信息
Nie Liang-ming, Xiao Xi-jun, Liang Mao-zhi, Liu Guan-jian
机构信息
Department of Thoracic Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):693-5.
OBJECTIVE
To investigate the impact of cardiopulmonary bypass (CPB) on free amino acid spectrum in plasma for patients with prosthetic valve replacement.
METHODS
The concentrations of the free amino acid in plasma for 22 patients with prosthetic valve replacement were measured with pre-column derivatization of high-performance liquid chromatography.
RESULTS
Compared with the preoperative data, the concentrations of some free amino acid in plasma decreased after the operation of cardiopulmonary bypass (CPB), especially some of the glucogenic amino acid and branch chain amino acid decreased significantly (P<0.05).
CONCLUSION
The operation of cardiopulmonary bypass (CPB) can decrease the concentrations of some free amino acid in plasma for patients with prosthetic valve replacement. It is essential to give these patients proper nutrition support during perioperative period.
目的
探讨体外循环（CPB）对人工瓣膜置换术患者血浆游离氨基酸谱的影响。
方法
采用高效液相色谱柱前衍生法测定22例人工瓣膜置换术患者血浆中游离氨基酸的浓度。
结果
与术前数据相比，体外循环（CPB）术后血浆中一些游离氨基酸的浓度降低，尤其是一些生糖氨基酸和支链氨基酸显著降低（P<0.05）。
结论
体外循环（CPB）手术可降低人工瓣膜置换术患者血浆中一些游离氨基酸的浓度。围手术期给予这些患者适当的营养支持至关重要。
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