朝鲜五加根中的三萜类化合物及其对NFAT转录的抑制活性。

Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription.

作者信息

Cai Xing Fu, Lee Im Seon, Shen Guanghai, Dat Nguyen Tien, Lee Jung Joon, Kim Young Ho

机构信息

College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.

出版信息

Arch Pharm Res. 2004 Aug;27(8):825-8. doi: 10.1007/BF02980173.

DOI:10.1007/BF02980173

PMID:15460442

Abstract

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).

摘要

从五加科植物辽东楤木的根中分离出两种三萜类化合物（1,4）和两种三萜类糖苷（2,3）。通过物理化学和光谱方法确定它们的结构分别为印加酸（1）、刺楤木皂苷A（2）、3-表桦木酸28-O-[α-L-鼠李吡喃糖基（1→4）-β-D-葡萄糖吡喃糖基（1→6）]-β-D-葡萄糖吡喃糖基酯（3）和熊果酸（4）。在这些化合物中，印加酸（1）对NFAT转录因子表现出强效抑制活性（IC50：12.65微摩尔）。