细柱五加叶中的羽扇豆烷型三萜糖苷

Lupane-triterpene glycosides from the leaves of Acanthopanax gracilistylus.

作者信息

Yook Chang-Soo, Liu Xiang-Qian, Chang Seung-Yeup, Park Sang-Yong, Nohara Toshihiro

机构信息

College of Pharmacy, Kyung-Hee University, Seoul, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2002 Oct;50(10):1383-5. doi: 10.1248/cpb.50.1383.

DOI:10.1248/cpb.50.1383

Abstract

A novel lupane-triterpene glycoside, called wujiapioside B (1), was isolated from the leaves of Acanthopanax gracilistylus (Araliaceae) together with three known lupane-triterpene glycosides, acankoreoside C (2), acantrifoside A (3) and 3-epibetulinic acid 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (4). Based on spectroscopic data, the chemical structure of 1 was determined as 3alpha,23-dihydroxy-lup-20(29)-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester. Compounds 2-3 were obtained for the first time from this plant and compound 4 has not been isolated from Acanthopanax genus yet.

摘要

从五加科植物细柱五加的叶子中分离出一种名为五加苷B（1）的新型羽扇豆烷型三萜糖苷，以及三种已知的羽扇豆烷型三萜糖苷，刺五加苷C（2）、刺五加苷A（3）和3-表桦木酸28-O-α-L-鼠李糖基-（1→4）-β-D-葡萄糖基-（1→6）-β-D-葡萄糖基酯（4）。根据光谱数据，确定1的化学结构为3α,23-二羟基-羽扇-20（29）-烯-28-酸28-O-α-L-鼠李糖基-（1→4）-β-D-葡萄糖基-（1→6）-β-D-葡萄糖基酯。化合物2-3首次从该植物中获得，化合物4尚未从五加属植物中分离得到。

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