益生菌可促进实验性营养不良中肠道萎缩的恢复。

Probiotics enhance the recovery of gut atrophy in experimental malnutrition.

作者信息

Dock Diana B, Aguilar-Nascimento José E, Latorraca Marcia Q

机构信息

Department of Nutrition & Dietetics, Nursing and Nutrition School, The Federal University of Mato Grosso, Brazil.

出版信息

Biocell. 2004 Aug;28(2):143-50.

PMID:15462565

Abstract

AIM

The aim of this study was to evaluate the effect of probiotics on the recovery of the bowel atrophy induced by malnutrition in rats.

METHODS

Twenty-and-six Wistar rats (200-250g) were fed with either a normoproteic (sham group, n=6) or a free-protein diet (n=20) during 12 days. Twelve malnourished rats were randomized to recover during 15 days with either a hydrolyzed diet (control group, n=6) or the same diet enriched with probiotics (Streptococcus thermophilus and Lactobacillus helveticus; probiotic group, n=6).

RESULTS

Probiotic group showed similar gain of body, liver and bowel weight than controls. At the jejunum, both the villus height (383+/-49 vs. 321+/-46mm; p=0.04) and crypt depth (157+/-31 vs. 125+/-10mm; p=0.04) were greater in probiotic group than in controls. The crypt depth at the cecum (214+/-22 vs. 169+/-43 mm; p=0.05) and the wall width at both the cecum (410+/-18 vs. 340+/-61 mm; p=0.02) and sigmoid (479+/-130 vs. 330+/-62 mm; p=0.03) were higher in probiotic than in control group.

CONCLUSION

Streptococcus thermophilus and Lactobacillus helveticus enhance the recovery of gut atrophy induced by malnutrition. Probiotics can be useful as oral adjuvants during the recovery of malnutrition.

摘要

目的

本研究旨在评估益生菌对大鼠营养不良所致肠道萎缩恢复的影响。

方法

26只体重200 - 250克的Wistar大鼠，12天内分别给予正常蛋白质饮食（假手术组，n = 6）或无蛋白饮食（n = 20）。12只营养不良大鼠随机分为两组，分别给予水解饮食（对照组，n = 6）或添加益生菌（嗜热链球菌和瑞士乳杆菌）的相同饮食（益生菌组，n = 6），持续15天进行恢复。

结果

益生菌组的体重、肝脏重量和肠道重量增加情况与对照组相似。在空肠，益生菌组的绒毛高度（383±49 vs. 321±46毫米；p = 0.04）和隐窝深度（157±31 vs. 125±10毫米；p = 0.04）均大于对照组。在盲肠，益生菌组的隐窝深度（214±22 vs. 169±43毫米；p = 0.05）以及盲肠壁宽度（410±18 vs. 340±61毫米；p = 0.02）和乙状结肠壁宽度（479±130 vs. 330±62毫米；p = 0.03）均高于对照组。