Demirer Seher, Aydintug Semih, Aslim Belma, Kepenekci Ilknur, Sengül Neriman, Evirgen Oya, Gerceker Devran, Andrieu Meltem Nalca, Ulusoy Cemal, Karahüseyinoglu Sercin
Ankara University School of Medicine, Ankara, Turkey.
Nutrition. 2006 Feb;22(2):179-86. doi: 10.1016/j.nut.2005.08.003.
Radiotherapy is an important aspect of multimodal cancer therapy, but radiation-induced acute intestinal injury is a common and serious problem. Disruption of morphologic mucosal integrity and normal bacterial microflora after abdominal radiation leads to malabsorption and bacterial translocation.
Lactobacillus bulgaricus strain isolated from yogurt was given as a probiotic to rats subjected to radiotherapy. On postradiation day 8 rats were killed. Mesenteric lymph nodes, liver, and spleen were excised for microbiologic examinations. Segments of jejunum, ileum, and colon were evaluated for the presence of inflammation, vascularity, and mucus cells.
The results of this study suggest that probiotics may have a protective effect on intestinal mucosa.
Probiotics added as substrates can be given by an oral or enteral route to patients who undergo radiotherapy to prevent radiation-induced enteritis and related malnutrition.
放射治疗是癌症多模式治疗的一个重要方面，但辐射诱发的急性肠道损伤是一个常见且严重的问题。腹部放疗后形态学上的黏膜完整性破坏和正常细菌微生物群紊乱会导致吸收不良和细菌移位。
将从酸奶中分离出的保加利亚乳杆菌作为益生菌给予接受放疗的大鼠。放疗后第8天处死大鼠。切除肠系膜淋巴结、肝脏和脾脏进行微生物学检查。评估空肠、回肠和结肠段的炎症、血管分布和黏液细胞情况。
本研究结果提示益生菌可能对肠黏膜有保护作用。
作为底物添加的益生菌可以经口服或肠内途径给予接受放疗的患者，以预防放射性肠炎及相关营养不良。
