Deloron P, Chougnet C
INSERM U13, Institut de Médecine et d'Epidémiologie A fricaines, 75944 Paris Cedex 19, France.
Parasitol Today. 1992 Nov;8(11):375-8. doi: 10.1016/0169-4758(92)90174-z.
Protection against Plasmodium falciparum malaria is usually considered to be the cumulative product of repeated exposure to parasites, and thus a function of age, in endemic areas. The recent outbreak of malaria in the central highlands of Madagascar gave Philippe Deloron and Claire Chougnet the opportunity to compare the incidence of malaria in children and young adults exposed to malaria for the first time, with that in older adults who spent their childhood in the study area before malaria control was introduced. Protection, as well as immune responses to two major P. falciparum antigens, was not related to age. Individuals older than 40 years were more protected than were younger adults. This increased protection was probably due to immunological memory.
在疟疾流行地区，通常认为对恶性疟原虫疟疾的防护是反复接触疟原虫的累积结果，因此是年龄的函数。马达加斯加中部高地最近爆发的疟疾疫情，让菲利普·德洛龙和克莱尔·舒涅有机会比较首次接触疟疾的儿童和年轻人与在疟疾控制措施实施前在研究地区度过童年的老年人的疟疾发病率。防护以及对两种主要恶性疟原虫抗原的免疫反应与年龄无关。40岁以上的人比年轻人受到的保护更好。这种增强的保护可能归因于免疫记忆。
