Pablo Huidobro-Toro J, Verónica Donoso M
Departamento de Fisiología, Unidad de Regulación Neurohumoral, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Casilla 114-D, Santiago, Chile.
Eur J Pharmacol. 2004 Oct 1;500(1-3):27-35. doi: 10.1016/j.ejphar.2004.07.008.
The historical role of noradrenaline as the predominant sympathetic neurotransmitter in vascular neuroeffector junctions has matured to include ATP and the modulator action of neuropeptide Y (NPY). Numerous studies with isolated blood vessels rings demonstrate the presence of key enzymes responsible for the synthesis of ATP, noradrenaline and NPY, their co-storage, and their electrically evoked release from sympathetic perivascular nerve terminals. Functional assays coincide to demonstrate the integral role of these neurochemicals in sympathetic reflexes. In addition, the detection of the diverse receptor populations for ATP, noradrenaline and NPY in blood vessels, either in the smooth muscle, endothelial cells or nerve endings, further contribute to the notion that sympathetic vascular reflexes encompass the orchestrated action of the noradrenaline and ATP, and their modulation by NPY. The future clinical opportunities of sympathetic co-transmission in the control of human cardiovascular diseases will be highlighted.
去甲肾上腺素作为血管神经效应器接头中主要的交感神经递质，其历史作用已发展到包括三磷酸腺苷（ATP）和神经肽Y（NPY）的调节作用。对离体血管环进行的大量研究表明，存在负责ATP、去甲肾上腺素和NPY合成的关键酶，它们共同储存，并从交感神经血管周围神经末梢电诱发释放。功能测定结果一致表明这些神经化学物质在交感反射中起不可或缺的作用。此外，在血管平滑肌、内皮细胞或神经末梢中检测到ATP、去甲肾上腺素和NPY的多种受体类型，进一步支持了交感神经血管反射包括去甲肾上腺素和ATP的协同作用以及NPY对它们的调节这一观点。本文将重点介绍交感神经共同传递在控制人类心血管疾病方面未来的临床应用前景。
