tau H2单倍型几乎完全起源于白种人。
The tau H2 haplotype is almost exclusively Caucasian in origin.
作者信息
Evans Whitney, Fung Hon Chung, Steele John, Eerola Johanna, Tienari Pentti, Pittman Alan, Silva Rohan de, Myers Amanda, Vrieze Fabienne Wavrant-De, Singleton Andrew, Hardy John
机构信息
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Neurosci Lett. 2004 Oct 21;369(3):183-5. doi: 10.1016/j.neulet.2004.05.119.
We have assessed the distribution of the tau H1/H2 haplotype in the publicly available reference series of samples with representatives of most racial groups. This analysis shows that the H2 haplotype is probably exclusively Caucasian in origin and its marginal occurrence in other racial groups is likely to reflect admixture. We discuss this observation in terms of the origin of the H2 haplotype and the epidemiology of the tauopathies.
我们在包含大多数种族群体代表的公开参考样本系列中评估了tau H1/H2单倍型的分布。该分析表明，H2单倍型可能完全起源于高加索人，其在其他种族群体中的少量出现可能反映了基因混合。我们从H2单倍型的起源和tau蛋白病的流行病学角度讨论了这一观察结果。
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