227Th-EDTMP: a potential therapeutic agent for bone metastasis.

作者信息

Washiyama Kohshin, Amano Ryohei, Sasaki Jun, Kinuya Seigo, Tonami Norihisa, Shiokawa Yoshinobu, Mitsugashira Toshiaki

机构信息

School of Health Sciences, Faculty of Medicine, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan.

出版信息

Nucl Med Biol. 2004 Oct;31(7):901-8. doi: 10.1016/j.nucmedbio.2004.05.001.

DOI:10.1016/j.nucmedbio.2004.05.001

PMID:15464392

Abstract

The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis.

摘要