α 发射器在放射治疗中的应用：从基础放射化学到临床研究——第 1 部分。
α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 1.
机构信息
Department of Radiology and Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Chemistry, Hunter College, New York, New York.
出版信息
J Nucl Med. 2018 Jun;59(6):878-884. doi: 10.2967/jnumed.116.186338. Epub 2018 Mar 15.
Abstract
With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.
摘要
α 发射放射性核素的粒子射程短，线性能量传递高，显示出很高的细胞杀伤效率。即使存在许多通过 α 粒子发射衰变的放射性核素，也只有少数放射性核素可以合理地用于治疗目的。包括放射性同位素的可用性和物理特性（例如半衰期）在内的因素会限制它们的广泛传播。本综述的第一部分将探讨 α 发射器的多样性、基本放射化学、限制和障碍。
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