Poldrack Russell A, Rodriguez Paul
Department of Psychology and Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.
Neurobiol Learn Mem. 2004 Nov;82(3):324-32. doi: 10.1016/j.nlm.2004.05.003.
Studies of human classification learning using functional neuroimaging have suggested that basal ganglia and medial temporal lobe memory systems may interact during learning. We review these results and outline a set of possible mechanisms for such interactions. Effective connectivity analyses suggest that interaction between basal ganglia and medial temporal lobe are mediated by prefrontal cortex rather than by direct connectivity between regions. A review of possible neurobiological mechanisms suggests that interactions may be driven by neuromodulatory systems in addition to mediation by interaction of inputs to prefrontal cortical neurons. These results suggest that memory system interactions may reflect multiple mechanisms that combine to optimize behavior based on experience.
使用功能性神经成像对人类分类学习进行的研究表明，基底神经节和内侧颞叶记忆系统在学习过程中可能会相互作用。我们回顾了这些结果，并概述了这种相互作用的一组可能机制。有效连接性分析表明，基底神经节和内侧颞叶之间的相互作用是由前额叶皮层介导的，而不是由区域之间的直接连接介导的。对可能的神经生物学机制的综述表明，除了前额叶皮层神经元输入的相互作用介导外，相互作用可能还由神经调节系统驱动。这些结果表明，记忆系统的相互作用可能反映了多种机制，这些机制结合起来根据经验优化行为。
