Mota Maria M, Giordano Silvia, Rodriguez Ana
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
Trends Mol Med. 2004 Oct;10(10):487-92. doi: 10.1016/j.molmed.2004.08.003.
Upon entering their host, Plasmodium sporozoites travel directly to the liver. Once there, they migrate through several hepatocytes before they infect a final one. During migration, sporozoites breach the plasma membrane of traversed hepatocytes, but to infect they must form a parasitophorous vacuole, in which the intra-hepatic form of the parasite grows and multiplies. During this period there is a remarkable parasite multiplication, but little is known about the requirements and strategies that are developed to be successful. Hepatocyte growth factor and its receptor on hepatocytes might enhance early Plasmodium development within these cells. We anticipate that this might be the basis for further studies on host-cell requirements for Plasmodium development.
疟原虫子孢子进入宿主后，会直接前往肝脏。到达肝脏后，它们会在感染最后一个肝细胞之前，穿过几个肝细胞。在迁移过程中，子孢子会穿透所穿过肝细胞的质膜，但要实现感染，它们必须形成一个寄生泡，寄生虫的肝内形式在其中生长和繁殖。在此期间，寄生虫会显著增殖，但对于其成功增殖所需的条件和策略，人们了解甚少。肝细胞生长因子及其在肝细胞上的受体可能会促进疟原虫在这些细胞内的早期发育。我们预计，这可能是进一步研究疟原虫发育所需宿主细胞条件的基础。
