Mota Maria M, Rodriguez Ana
Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Cell Microbiol. 2004 Dec;6(12):1113-8. doi: 10.1111/j.1462-5822.2004.00460.x.
Malaria starts with the infection of the liver by Plasmodium sporozoites. This form of the parasite migrates through several host cells breaching their plasma membranes before infecting a final hepatocyte which they enter forming a parasitophorous vacuole. It is still controversial why Plasmodium sporozoites migrate through host cells. By reviewing the most recent literature, we hope to give an insight on the different steps of host invasion in which migration through cells is involved and on the possible role for this mechanism in infection.
疟疾始于疟原虫子孢子感染肝脏。这种寄生虫形式会穿过几个宿主细胞，突破它们的质膜，然后感染最终的肝细胞，并进入其中形成一个寄生泡。疟原虫子孢子为何穿过宿主细胞仍存在争议。通过回顾最新文献，我们希望能深入了解涉及细胞迁移的宿主入侵的不同步骤，以及这种机制在感染中可能发挥的作用。
