Marashi Sayed-Amir, Najafabadi Hamed Shateri
Department of Biotechnology, Faculty of Science, University of Tehran, Enghelab Ave., Tehran, Iran.
Biochem Biophys Res Commun. 2004 Nov 5;324(1):1-2. doi: 10.1016/j.bbrc.2004.08.213.
A. Fuglsang [Biochem. Biophys. Res. Commun. 317 (2004) 957-964] suggested that effective number of codons for individual amino acids (Nc-values) should be re-adjusted to the number of synonymous codons of those amino acids, in order to prevent the overestimation of the effective number of codons. Here, it is shown that re-adjustment at the level of individual amino acids results in loss of considerable amounts of information. Furthermore, we have shown that theoretical Nc-values are functions of GC3s (and GC1s); as a result, when an amino acid Nc-value exceeds the related theoretical Nc-value, the implication of re-adjustment depends on the GC composition of the gene.
A. 富格桑[《生物化学与生物物理研究通讯》317(2004)957 - 964]提出，为防止对密码子有效数量的高估，应将单个氨基酸的密码子有效数量（Nc值）重新调整为这些氨基酸的同义密码子数量。在此表明，在单个氨基酸水平上进行重新调整会导致大量信息丢失。此外，我们已经表明理论Nc值是GC3s（和GC1s）的函数；因此，当一个氨基酸的Nc值超过相关理论Nc值时，重新调整的含义取决于基因的GC组成。
