嗅觉测试在“鲁巴格病”或X连锁肌张力障碍-帕金森综合征中表现异常：一项初步研究。

Smell testing is abnormal in 'lubag' or X-linked dystonia-parkinsonism: a pilot study.

作者信息

Evidente Virgilio Gerald H, Esteban Raymund P, Hernandez Jose Luis, Natividad Filipinas F, Advincula Joel, Gwinn-Hardy Katrina, Hardy John, Singleton Amanda, Singleton Andrew

机构信息

Department of Neurology, Mayo Clinic, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA.

出版信息

Parkinsonism Relat Disord. 2004 Oct;10(7):407-10. doi: 10.1016/j.parkreldis.2004.04.011.

DOI:10.1016/j.parkreldis.2004.04.011

PMID:15465396

Abstract

We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with 'Lubag' or X-linked dystonia-parkinsonism and 20 control subjects matched by sex, age, educational background, smoking history, and geographical origin. The mean ccUPSIT score of Lubag patients (18 +/- 3.19) was statistically lower (P = 0.003) than controls (20.5 +/- 3.02). The smell scores did not correlate with phenotype, severity of dystonia, or duration of disease. Nine of 20 Lubag patients (45%) had ccUPSIT scores below the mean, with the lowest score being 11. This pilot study suggests that olfactory dysfunction may occur in Lubag patients.

摘要

我们对20名患有“Lubag”或X连锁肌张力障碍-帕金森综合征的患者以及20名在性别、年龄、教育背景、吸烟史和地理来源方面相匹配的对照受试者进行了一项经过文化校正的宾夕法尼亚大学嗅觉识别测试（ccUPSIT），该测试由25种气味项目组成。Lubag患者的ccUPSIT平均得分（18±3.19）在统计学上低于对照组（20.5±3.02）（P = 0.003）。嗅觉得分与表型、肌张力障碍严重程度或病程无关。20名Lubag患者中有9名（45%）的ccUPSIT得分低于平均值，最低分为11分。这项初步研究表明，Lubag患者可能存在嗅觉功能障碍。