左旋多巴对帕金森病患者功能平衡的影响。
Levodopa effect upon functional balance of Parkinson's disease patients.
作者信息
Nova Isabella C, Perracini Mônica R, Ferraz Henrique B
机构信息
Movement Disorders Unit, Department of Neurology, Universidade Federal de São Paulo, Al. Casa Branca, 805 Ap. 141, 01408-001 São Paulo, Brazil.
出版信息
Parkinsonism Relat Disord. 2004 Oct;10(7):411-5. doi: 10.1016/j.parkreldis.2004.04.004.
OBJECTIVE
The aim of this study was to evaluate functional balance in PD patients taking levodopa during their 'on' and 'off' phases.
DESIGN
We evaluated 23 PD patients who were manifesting fluctuations of levodopa effect. All patients were assessed by Hoehn-Yahr, UPDRS-III and Schwab-England rating scales and by the Berg functional balance scale during a practically defined 'off' (at least after 12 h the last levodopa intake) and 'on' (the mobile state induced by the drug) phases.
RESULTS
Mean scores obtained for all scales showed improvements during the 'on' phase of levodopa and all of the comparisons were statistically significant. Mean scores of Berg scale moved from 31.7 during the 'off' phase to 42.7 during the 'on' phase. Mean UPDRS 'off' and 'on' scores were 50.6 and 32.0, respectively.
CONCLUSION
We conclude that Berg functional balance scale is able to detect changes in balance and that levodopa can modify the postural instability of PD patients.
目的
本研究旨在评估帕金森病（PD）患者在左旋多巴“开”期和“关”期的功能平衡。
设计
我们评估了23名表现出左旋多巴效应波动的PD患者。所有患者在实际定义的“关”期（至少在最后一次服用左旋多巴12小时后）和“开”期（药物诱导的活动状态）通过Hoehn-Yahr量表、统一帕金森病评定量表第三部分（UPDRS-III）、施瓦布-英格兰量表以及伯格功能平衡量表进行评估。
结果
所有量表在左旋多巴“开”期的平均得分均有改善，所有比较均具有统计学意义。伯格量表的平均得分从“关”期的31.7提高到“开”期的42.7。UPDRS“关”期和“开”期的平均得分分别为50.6和32.0。
结论
我们得出结论，伯格功能平衡量表能够检测平衡变化，且左旋多巴可改善PD患者的姿势不稳。
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