Taghizadeh Ghorban, Fereshtehnejad Seyed Mohammad, Martinez-Martin Pablo, Joghataei Mohammad Taghi, Mahdizadeh Fatemeh, Sabbaghi Sajad, Goudarzi Sepide, Meimandi Mahsa, Habibi Sayed Amir Hasan, Mehdizadeh Maryam
Department of Occupational Therapy, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Science, Tehran, Iran.
Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Basic Clin Neurosci. 2021 Jan-Feb;12(1):69-78. doi: 10.32598/bcn.12.1.882.11. Epub 2021 Jan 1.
Freezing of gait, a common PD motor symptom, could increase the risk of falling. This study aimed to investigate the clinimetric attributes of the Freezing of Gait Questionnaire (FOGQ) for people with Parkinson disease in the "off" state.
A total of 115 patients with Parkinson disease (PD; mean age, 60.25 years) were included. Acceptability, internal consistency (by the Cronbach alpha, and test-retest by Intraclass Correlation [ICC]), and reliability of the Persian-translated version of the FOGQ were examined. Dimensionality was estimated by Exploratory Factor Analysis (EFA). Fall efficacy scale-international, unified Parkinson disease rating scale-II, Berg balance scale, functional reach test, and Parkinson disease questionnaire-39 were applied to determine the convergent validity. Diagnostic accuracy for obtaining optimal cutoff point, separating faller and non-faller groups, was analyzed by Receiver Operating Characteristics (ROC) curve analysis and Area Under the Curve (AUC). All tests were carried out in an "off" state.
The Cronbach alpha was high (α=0.92). The test-retest showed high reliability (ICC=0.89). The FOGQ was unidimensional according to the EFA and had acceptable convergent validity with moderate to high correlation with other clinical scales. The optimal cutoff point to discriminate fallers from non-fallers during the "off" state was 9/10, with an AUC of 0.92.
Our results suggest that the FOGQ has appropriate reliability, validity, and discriminative ability for measuring FOG in patients with PD during the "off" state.
冻结步态是帕金森病常见的运动症状，会增加跌倒风险。本研究旨在调查帕金森病患者“关”期冻结步态问卷（FOGQ）的临床测量属性。
共纳入115例帕金森病患者（平均年龄60.25岁）。对FOGQ波斯语翻译版的可接受性、内部一致性（通过Cronbach α系数）和重测信度（组内相关系数[ICC]）进行了检验。通过探索性因子分析（EFA）估计维度。应用跌倒效能量表-国际版、统一帕金森病评定量表-II、伯格平衡量表、功能性伸展测试和帕金森病问卷-39来确定收敛效度。通过受试者工作特征（ROC）曲线分析和曲线下面积（AUC）分析获得最佳截断点以区分跌倒者和非跌倒者组的诊断准确性。所有测试均在“关”期进行。
Cronbach α系数较高（α = 0.92）。重测显示出较高的信度（ICC = 0.89）。根据EFA，FOGQ是单维的，并且与其他临床量表具有中度至高相关性，具有可接受的收敛效度。在“关”期区分跌倒者和非跌倒者的最佳截断点为9/10，AUC为0.92。
我们的结果表明，FOGQ在测量帕金森病患者“关”期的冻结步态方面具有适当的信度、效度和区分能力。
