Gimeno L, Corradi A, Cobos I, Consalez G G, Martinez S
Instituto de Neurociencias, CSIC-UMH, Campus de San Juan, Apdo correos 18, 03550 Alicante, Spain.
Gene Expr Patterns. 2004 Oct;4(6):749-54. doi: 10.1016/j.modgep.2004.03.007.
Ezrin is a member of the Ezrin, Radixin, Moesin (ERM) proteins family that are proposed to act as linkers between the cytoskeleton and plasma membrane. Ezrin regulates cell-cell and cell-matrix interactions playing a role in the regulation of cellular adhesion, movement and morphology in epithelia. Alterations in the expression of Ezrin and other members of ERM family have also been observed in brain tumours. Here we report the expression pattern of Ezrin during mouse neural development, from early stages to postnatal stages. In young and middle gestation embryos, Ezrin is expressed in the roof plate of the neural tube, in the presumptive domain of the choroidal plexus, and in some precise domains of ventricular epithelium. These domains are distributed in basal and alar neuroepithelial regions, some of them in relation to the expression of cadherins. At later gestation and postnatal stages, Ezrin expression is maintained on the mature choroidal plexus and is weakly detected in the proliferative regions of the mature brain.
埃兹蛋白是埃兹蛋白、根蛋白、膜突蛋白（ERM）家族的成员之一，该家族被认为是细胞骨架与质膜之间的连接蛋白。埃兹蛋白调节细胞间和细胞与基质的相互作用，在上皮细胞的细胞黏附、运动和形态调节中发挥作用。在脑肿瘤中也观察到埃兹蛋白和ERM家族其他成员表达的改变。在此，我们报告埃兹蛋白在小鼠神经发育过程中从早期到出生后阶段的表达模式。在妊娠早期和中期的胚胎中，埃兹蛋白在神经管的顶板、脉络丛的假定区域以及室管膜上皮的一些特定区域表达。这些区域分布在基底和翼神经上皮区域，其中一些与钙黏蛋白的表达有关。在妊娠后期和出生后阶段，埃兹蛋白在成熟脉络丛上持续表达，在成熟脑的增殖区域中检测到的表达较弱。
