Kobayashi N, Tamai H, Takii M, Matsubayashi S, Nakagawa T
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Acta Psychiatr Scand. 1992 Jan;85(1):6-10. doi: 10.1111/j.1600-0447.1992.tb01433.x.
Abnormal glucose tolerance is often found in patients with anorexia nervosa (AN). We attempted to evaluate pancreatic B-cell functioning after intravenous glucagon administration. Fourteen patients with the restricting type of AN (percentage of ideal body weight 71.5 +/- 1.6%, mean +/- SE) and 6 patients with the bulimic type of AN (77.0 +/- 3.0%) were studied. After an overnight fast, glucagon (0.02 mg/kg) was injected i.v. into all subjects and 6 normal controls. Blood samples were obtained at 0, 5, 30, 60, 90 and 120 min to measure blood glucose (BS), serum insulin (IRI) and C-peptide (CPR). The same tests were repeated in 8 patients with restricting AN after therapy and restoration of body weight (85.9 +/- 1.0% of ideal body weight). BS responses did not differ among the groups. Peak serum levels (5 min) of both IRI and CPR in restricting AN patients were significantly lower than those in bulimic AN patients and in normal controls. BS, IRI and CPR concentrations did not change significantly following restoration of body weight. Pancreatic B-cell dysfunction after glucagon administration was observed in restricting AN patients and the abnormality persisted after short-term weight restoration.
神经性厌食症（AN）患者常出现糖耐量异常。我们试图评估静脉注射胰高血糖素后胰腺β细胞的功能。研究了14例限制型AN患者（理想体重百分比为71.5 +/- 1.6%，均值 +/- 标准误）和6例暴食型AN患者（77.0 +/- 3.0%）。在禁食过夜后，对所有受试者及6名正常对照静脉注射胰高血糖素（0.02 mg/kg）。在0、5、30、60、90和120分钟采集血样，测量血糖（BS）、血清胰岛素（IRI）和C肽（CPR）。8例限制型AN患者在治疗并恢复体重后（理想体重的85.9 +/- 1.0%）重复进行相同测试。各组的血糖反应无差异。限制型AN患者的IRI和CPR血清峰值水平（5分钟时）显著低于暴食型AN患者及正常对照。体重恢复后，BS、IRI和CPR浓度无显著变化。在限制型AN患者中观察到静脉注射胰高血糖素后胰腺β细胞功能障碍，且在短期体重恢复后该异常仍持续存在。
