Tomasik Przemyslaw J, Sztefko Krystyna, Starzyk Jerzy, Rogatko Iwona, Szafran Zdzisław
Department of Clinical Biochemistry, University Children's Hospital, Jagiellonian University, Wielicka St. 265, 30-663 Krakow, Poland.
Psychoneuroendocrinology. 2005 May;30(4):364-72. doi: 10.1016/j.psyneuen.2004.10.003. Epub 2005 Jan 18.
Entero-insular axis plays an important role in generating satiety signal. Thus disturbances in this axis may influence the course of anorexia nervosa. The aim of the study was analysis of the function of the hormonal part of the entero-insular axis in girls with anorexia nervosa. Thirteen girls with anorexia nervosa and in 10 healthy girls were studied. Each girl was subjected to oral glucose tolerance test and standard meal test. Blood was collected before stimulation and within 15, 30, 60, and 120 min thereafter. The concentrations of all peptides were determined by radioimmunoassay commercial kits. Fasted and postprandial levels of these peptides as well as integrated outputs were measured. Fasting insulin concentration was significantly higher in the group of girls with anorexia nervosa than in the control group (p<0.03). What more in girls with anorexia the integrated output of insulin was significantly lower in oral glucose tolerance test than after the meal (p<0.001). Also the integrated output of glucagon in both tests was higher in the group of girls with anorexia than in the control group. The mean output of pancreatic polypeptide and cholecystokinin in anorexia group was significantly higher (p<0.001 in both cases) than that in the control group but only after the test meal. The integrated outputs of gastric inhibitory peptide in both tests were significantly higher in anorectic girls than those in the control group (oral glucose tolerance test, p<0.02; meal test, p<0.001), However, mean values of the integrated output of glucagon-like peptide 1 in both tests were significantly higher in the control group than in the girls with anorexia (p<0.001 in each case). Highly significant correlation was found between glucose concentration and the concentrations of insulin, cholecystokinin, and gastric inhibitory peptide in both tests and for the both groups. In the anorectic girls, significant correlation between insulin concentration and the concentration of gastric inhibitory peptide was found after both stimulation tests and between insulin and cholecystokinin after oral glucose only.
the disturbed secretion of the hormones of entero-insular axis after the meal in anorectic girls may have negative influence on the course of anorexia nervosa. This disease has no effect on the incretin function of cholecystokinin, gastric inhibitory peptide and glucagon-like peptide 1.
肠-胰岛轴在产生饱腹感信号方面起着重要作用。因此，该轴的紊乱可能会影响神经性厌食症的病程。本研究的目的是分析神经性厌食症女孩肠-胰岛轴激素部分的功能。对13名神经性厌食症女孩和10名健康女孩进行了研究。每个女孩都接受了口服葡萄糖耐量试验和标准餐试验。在刺激前以及刺激后15、30、60和120分钟采集血液。所有肽的浓度通过放射免疫分析商业试剂盒测定。测量了这些肽的空腹和餐后水平以及综合输出量。神经性厌食症女孩组的空腹胰岛素浓度显著高于对照组（p<0.03）。此外，在口服葡萄糖耐量试验中，神经性厌食症女孩的胰岛素综合输出量显著低于餐后（p<0.001）。在两项试验中，神经性厌食症女孩组的胰高血糖素综合输出量也高于对照组。厌食症组胰多肽和胆囊收缩素的平均输出量显著高于对照组（两种情况均p<0.001），但仅在试验餐后。在两项试验中，厌食症女孩胃抑制肽的综合输出量均显著高于对照组（口服葡萄糖耐量试验，p<0.02；餐试验，p<0.001）。然而，在两项试验中，胰高血糖素样肽1综合输出量的平均值在对照组中显著高于神经性厌食症女孩（每种情况均p<0.001）。在两项试验中，两组的葡萄糖浓度与胰岛素、胆囊收缩素和胃抑制肽的浓度之间均发现高度显著的相关性。在厌食症女孩中，在两项刺激试验后均发现胰岛素浓度与胃抑制肽浓度之间存在显著相关性，仅在口服葡萄糖后胰岛素与胆囊收缩素之间存在显著相关性。
厌食症女孩餐后肠-胰岛轴激素分泌紊乱可能对神经性厌食症的病程产生负面影响。这种疾病对胆囊收缩素、胃抑制肽和胰高血糖素样肽1的肠促胰岛素功能没有影响。
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