Krystal J H, Leaf P J, Bruce M L, Charney D S
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Acta Psychiatr Scand. 1992 Jan;85(1):77-82. doi: 10.1111/j.1600-0447.1992.tb01447.x.
Findings are reported evaluating the effects of aging and alcoholism histories on the 6-month prevalence rates of panic disorder. The data were collected in 5 communities as part of the Epidemiologic Catchment Area (ECA) study: New Haven, CT; Baltimore, MD; St. Louis, MO; Durham, NC; and Los Angeles, CA. Reanalysis of ECA data provided additional support for a decline in the prevalence of panic disorder among elderly people. In addition, the presence of a history of alcohol abuse or dependence was associated with significantly elevated panic disorder rates in younger individuals, but an earlier decline in panic disorder prevalence with age, regardless of gender. These findings offer preliminary support for neurodevelopmental hypotheses for the onset and outgrowing of panic disorder. They also highlight the impact of alcoholism on the course of panic disorder.
报告了关于评估衰老和酗酒史对惊恐障碍6个月患病率影响的研究结果。这些数据是在5个社区收集的，作为流行病学集水区（ECA）研究的一部分：康涅狄格州纽黑文市；马里兰州巴尔的摩市；密苏里州圣路易斯市；北卡罗来纳州达勒姆市；以及加利福尼亚州洛杉矶市。对ECA数据的重新分析为老年人中惊恐障碍患病率的下降提供了额外支持。此外，有酒精滥用或依赖史与年轻个体中惊恐障碍患病率显著升高相关，但无论性别，惊恐障碍患病率随年龄增长更早下降。这些发现为惊恐障碍的发病和消退的神经发育假说提供了初步支持。它们还突出了酗酒对惊恐障碍病程的影响。
