Segui J, Salvador L, Canet J, Aragón C, Herrera C
Hospital Central de la Alianza, Barcelona.
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1995 Nov-Dec;23(6):288-92.
Among 148 patients presenting Panic Disorder (DSM-III-R), 18.9% have an alcohol disorder, 8.8% present abuse and 10.1% dependence. Mean age of onset of alcoholism was much earlier than panic disorder. Patients with alcoholism: a) are males more frequently (0.001); b) present more alcoholism in first grade relatives (0.05); c) use more often other drugs like: tobacco (0.01), coffee (p < 0.01), cocaine (p < 0.01) and cannabis (p < 0.001), d) patients with alcoholism refer a greater severity of their panic attacks when drinking large amounts of alcohol (25%) than the group without these problems (2.5%) (x2:14.8) (p < 0.001) e) according to the GAS the overall level of performance is lower in alcoholics (p < 0.005); f) present more anxiety measured by the HARS (p < 0.01), and therefore have more comorbid anxiety disorders according to DSM-III-R (p < 0.01). The clinical significance of these findings is discussed.
在148例患有惊恐障碍（DSM-III-R）的患者中，18.9%存在酒精障碍，8.8%为酒精滥用，10.1%为酒精依赖。酒精中毒的平均发病年龄比惊恐障碍早得多。患有酒精中毒的患者：a）男性更为常见（0.001）；b）一级亲属中酒精中毒的情况更多（0.05）；c）更常使用其他药物，如：烟草（0.01）、咖啡（p<0.01）、可卡因（p<0.01）和大麻（p<0.001）；d）与无这些问题的组相比，酒精中毒患者在大量饮酒时（25%）惊恐发作的严重程度更高，而无这些问题的组为2.5%（x2:14.8）（p<0.001）；e）根据大体评定量表（GAS），酒精中毒患者的总体功能水平较低（p<0.005）；f）通过汉密尔顿焦虑量表（HARS）测量的焦虑程度更高（p<0.01），因此根据DSM-III-R，共患焦虑障碍的情况更多（p<0.01）。本文讨论了这些发现的临床意义。
