Control Clin Trials. 2004 Oct;25(5):458-71. doi: 10.1016/j.cct.2004.08.002.
SEARCH for Diabetes in Youth is an observational, multicenter study focusing on physician-diagnosed diabetes in individuals <20 years old. The study will estimate the population prevalence and incidence of diabetes by type, age, gender, and ethnicity and develop practical approaches to diabetes classification in 5 million children ( approximately 6% of the <20 U.S. population) with wide ethnic and socioeconomic representation from four geographically defined populations and two health plans. An estimated 6000 prevalent and 800 incident diabetes cases per year will be identified with annual follow-up. Cases will be ascertained through clinical and nonclinical resources or partnerships at each site. Data collection involves patient interviews, physical examinations, laboratory measurements (diabetes autoantibodies, fasting/stimulating C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine), medical records reviews, and documentation of risk factors for complications and processes of care.
青少年糖尿病研究（SEARCH for Diabetes in Youth）是一项观察性多中心研究，聚焦于20岁以下个体经医生诊断的糖尿病。该研究将按类型、年龄、性别和种族估计糖尿病的人群患病率和发病率，并针对来自四个地理区域界定人群和两个健康计划、具有广泛种族和社会经济代表性的500万儿童（约占美国20岁以下人口的6%）制定糖尿病分类的实用方法。通过年度随访，预计每年将识别出6000例糖尿病现患病例和800例新发病例。病例将通过各研究点的临床和非临床资源或合作关系来确定。数据收集包括患者访谈、体格检查、实验室检测（糖尿病自身抗体、空腹/刺激后C肽、糖化血红蛋白、血糖、血脂、尿白蛋白、肌酐）、病历审查以及并发症危险因素和护理过程的记录。
