Moore Kelly R, Harwell Todd S, McDowall Janet M, Helgerson Steven D, Gohdes Dorothy
Billings Area Indian Health Service, Billings, Montana, USA.
J Pediatr. 2003 Sep;143(3):368-71. doi: 10.1067/S0022-3476(03)00295-6.
To estimate the prevalence and incidence of type 2 diabetes among American Indian youth.
Medical records were reviewed annually for all patients with diabetes who were <20 years of age at 6 Indian Health Service facilities in Montana and Wyoming. All cases < or =5 years of age or weight per age < or =10th percentile at diagnosis or with islet cell antibodies were considered as probable type 1. Among the remaining cases, probable type 2 diabetes was defined when a child had one or more of the following characteristics: weight per age > or =95th percentile or acanthosis nigricans at diagnosis, elevated C-peptide or insulin, family history of type 2 diabetes; treatment with oral agents with or without insulin or no hypoglycemic therapy after 1 year of follow-up.
From 1999 to 2001, 53% of prevalent cases and 70% of incident cases were categorized as probable type 2 diabetes. The average annual prevalence of probable type 1 and type 2 diabetes was 0.7 and 1.3 per 1000. The average annual incidence rates for probable type 1, and type 2 diabetes were 5.8, 23.3 per 100,000.
The incidence of probable type 2 diabetes was approximately 4 times higher than type 1 diabetes among American Indian youth in Montana and Wyoming
评估美国印第安青年中2型糖尿病的患病率和发病率。
对蒙大拿州和怀俄明州6家印第安卫生服务机构中所有年龄小于20岁的糖尿病患者的病历进行年度审查。所有年龄小于或等于5岁、诊断时体重低于或等于同年龄第10百分位数或伴有胰岛细胞抗体的病例被视为可能的1型糖尿病。在其余病例中,当儿童具有以下一项或多项特征时,定义为可能的2型糖尿病:诊断时年龄别体重高于或等于第95百分位数或黑棘皮症、C肽或胰岛素升高、2型糖尿病家族史;随访1年后接受口服降糖药治疗(无论是否联用胰岛素)或未接受降糖治疗。
1999年至2001年,53%的现患病例和70%的新发病例被归类为可能的2型糖尿病。可能的1型和2型糖尿病的年平均患病率分别为每1000人中有0.7例和1.3例。可能的1型和2型糖尿病的年平均发病率分别为每10万人中有5.8例和23.3例。
在蒙大拿州和怀俄明州的美国印第安青年中,可能的2型糖尿病发病率约为1型糖尿病的4倍。