部分交叉设计在早期随机预防试验中的效用。
The utility of partial cross-over designs in early phase randomized prevention trials.
作者信息
Hutson Alan D, Reid Mary E
机构信息
University at Buffalo, Department of Biostatistics, Farber Hall Room 249A, 3435 Main St., Buffalo, NY 14214-3000, USA.
出版信息
Control Clin Trials. 2004 Oct;25(5):493-501. doi: 10.1016/j.cct.2004.07.005.
PMID:15465618
Abstract
In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.
摘要
在本笔记中，我们概述了部分交叉设计对于一类实验的益处，这类实验关注的是剂量与安慰剂的累积效应。我们设计策略的目标是，在II期试验环境中，以最少的假设高效回答几个复杂问题，同时着眼于规划III期研究。
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