Laslo-Baker Dionne, Barrera Maru, Knittel-Keren Dafna, Kozer Eran, Wolpin Jacob, Khattak Sohail, Hackman Richard, Rovet Joanne, Koren Gideon
Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Arch Pediatr Adolesc Med. 2004 Oct;158(10):956-61. doi: 10.1001/archpedi.158.10.956.
Many women of reproductive age are employed in industries involving exposure to organic solvents. Animal toxicological studies and human case reports demonstrate that high exposure to solvents causes neurodevelopmental toxicity in exposed offspring. Data from occupationally exposed women and their children are few.
To compare the cognitive, language, and motor performance and the behavioral achievements of children whose mothers were exposed occupationally to organic solvents during pregnancy with those of a matched unexposed control group.
Thirty-two pregnant women occupationally exposed to organic solvents were recruited during pregnancy and followed up. Their offspring (age range, 3-9 years) were tested for cognitive functioning (IQ), language, visual-motor functioning, and behavioral functioning and were compared with a matched unexposed control group that was recruited and tested in a similar manner. Examiners were blinded to the exposure status.
Mothers occupationally exposed to organic solvents did not differ significantly from matched controls in demographic variables. After controlling for potential confounding because of maternal IQ and maternal education, children exposed in utero to organic solvents obtained lower scores on subtests of intellectual, language, motor, and neurobehavioral functioning.
In utero exposure to organic solvents is associated with poorer performance on some specific subtle measures of neurocognitive function, language, and behavior. Reducing exposure in pregnancy is merited until more refined risk assessment is possible. Further studies that address exposure to specific solvents, dose, and gestational timing of exposure are needed.
许多育龄女性受雇于涉及接触有机溶剂的行业。动物毒理学研究和人类病例报告表明，高剂量接触溶剂会导致接触溶剂的后代出现神经发育毒性。职业接触溶剂的女性及其子女的数据较少。
比较孕期职业接触有机溶剂的母亲所生子女与匹配的未接触溶剂对照组子女在认知、语言、运动能力及行为方面的表现。
招募了32名孕期职业接触有机溶剂的孕妇并进行随访。对其子女（年龄范围3至9岁）进行认知功能（智商）、语言、视觉运动功能及行为功能测试，并与以类似方式招募和测试的匹配未接触溶剂对照组进行比较。检查人员对接触状态不知情。
职业接触有机溶剂的母亲在人口统计学变量方面与匹配的对照组无显著差异。在控制了因母亲智商和母亲教育程度可能产生的混杂因素后，子宫内接触有机溶剂的儿童在智力、语言、运动和神经行为功能的子测试中得分较低。
子宫内接触有机溶剂与某些特定的神经认知功能、语言和行为的细微测量指标表现较差有关。在能够进行更精确的风险评估之前，孕期减少接触有机溶剂是值得的。需要进一步研究特定溶剂的接触、剂量以及接触的孕周。
